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首页> 外文OA文献 >Correlation of plasma monocyte chemoattractant protein-1 (MCP-1) and monocyte inflammatory protein-1α (MIP-1α) levels with disease activity and clinical course of sarcoidosis
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Correlation of plasma monocyte chemoattractant protein-1 (MCP-1) and monocyte inflammatory protein-1α (MIP-1α) levels with disease activity and clinical course of sarcoidosis

机译：血浆单核细胞趋化蛋白-1（MCP-1）和单核细胞炎性蛋白-1α（MIP-1α）水平与疾病活动和结节病临床病程的相关性

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MCP-1 and MIP-1α exhibit chemotactic activity toward macrophages/monocytes and induce the production of inflammatory cytokines affecting granuloma formation. Up-regulated expression of MCP-1 and MIP-1α in the affected organ of sarcoidosis has been shown; however, the relationship between their plasma levels and the clinical course of this disease has not been determined. In the present study we measured plasma MCP-1 and MIP-1α levels in 26 patients with active sarcoidosis by ELISA in order to assess the state of MCP-1 and MIP-1α in this disease. Most patients in this study (21/26) had clinical evidence of extrathoracic disease in addition to pulmonary involvement. In addition, a high proportion of patients (n = 15) showed spontaneous remission of disease, whereas five patients showed no spontaneous remission and six patients were treated with corticosteroids over the 2-year period of study. At the time of diagnosis, both plasma MCP-1 and MIP-1α levels in patients with active sarcoidosis were significantly higher than in the normal controls. The levels of these cytokines in patients with extrathoracic disease were compatible with those in patients without extrathoracic disease. A longitudinal evaluation of plasma MCP-1 and MIP-1α levels showed that the changes in both cytokines were closely related to the clinical course of sarcoidosis. These results suggest that plasma MCP-1 and MIP-1α may be useful parameters for monitoring the clinical course of sarcoidosis. In addition, plasma MCP-1 and MIP-1α may reflect subclinical evidence of extrathoracic sarcoidosis and may play a role in initiating monocyte migration into the tissue.
机译：MCP-1和MIP-1α对巨噬细胞/单核细胞表现出趋化活性，并诱导产生影响肉芽肿形成的炎性细胞因子。已经显示结节病的受影响器官中MCP-1和MIP-1α的表达上调；然而，他们的血浆水平与该疾病的临床病程之间的关系尚未确定。在本研究中，我们通过ELISA测定了26例活动性结节病患者的血浆MCP-1和MIP-1α水平，以评估该疾病中MCP-1和MIP-1α的状态。本研究中的大多数患者（21/26）除肺部受累外，还有胸外疾病的临床证据。此外，在为期两年的研究中，有很大比例的患者（n = 15）表现出疾病的自发缓解，而有5位患者没有表现出自发缓解，有6位患者接受了糖皮质激素治疗。在诊断时，活动性结节病患者的血浆MCP-1和MIP-1α水平均显着高于正常对照组。胸外疾病患者的这些细胞因子水平与无胸外疾病的患者的细胞因子水平相符。对血浆MCP-1和MIP-1α水平的纵向评估表明，两种细胞因子的变化均与结节病的临床病程密切相关。这些结果表明血浆MCP-1和MIP-1α可能是监测结节病临床过程的有用参数。此外，血浆MCP-1和MIP-1α可能反映出胸外结节病的亚临床证据，并可能在启动单核细胞迁移入组织中发挥作用。

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